Dermal penetration and models

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Data from exposures in volunteers i. Yu et al Excised human skin is most commonly obtained from plastic surgery or cadavers, and in both cases, appropriate ethical approval is required to use the tissue. The concentrations of D 4 in exhaled air and plasma were higher in women than in men. Species differences in percutaneous absorption of nicorandil.

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The skin is not only a convenient portal to the systemic circulation but also a logical site of application for treatment of various localized skin disorders, such as skin cancers, inflammatory illnesses, and damaged skin.

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Pharmacokinetic models of dermal absorption.

For D 5the ratio of the concentration of D 5 in the venous return to the concentration of D 5 in exhaled air was used to estimate model parameters describing the pool of D 5 sequestered in the blood. A novel chimeric model consisting of a human artificial 3-D skin construct grafted onto the back of SCID mice has also been reported. A comparison between in vitro rat and human and in vivo rat skin absorption studies. Marrakchi S, Maibach HI. For example, epidermal VEGF-knockout mice were used to identify a specific role for epidermal VEGF in the maintenance of epidermal permeability-barrier homeostasis and pointed to the disruption of VEGF pathways in the development of psoriasis.

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